3 PM Homburg, Germany
As of 11:45 AM today, Coleman was "stable" in general but his lungs continue to be unstable and a great concern. His bleeding was somewhat improved and there is discussion of resuming the Activated Protein C therapy this evening. Furthermore the doctors are doing additional imaging to deterine if there is any improvement in the VOD from therapy that was administered prior to his bleeding problem.
Please bear in mind that "stable" is a misleading term, but the best available. Stable in this context should be read to mean that Coleman is maintained by a series of extreme drugs and devices (ventilator/dialysis/etc) that allow him to live. Liver failure is progressive and like a series of dominos going in many directions but all with a common origin, Coleman's body is beset by many competing attacks simultaneously. This is further complicated by his leukemia, which by most estimates appears to be incidental to the liver failure. The first domino is what caused his liver to fail and is unknown - a toxin of some sort most likely - almost definitely not leukemia. The second domino is the liver failure itself (technically VOD) and from this domino many paths branch out and intertwine. The path causing his breathing difficulty is "capillary leakage" - fluid build up throughout his body, especially around and in his lungs.
A liver biopsy (which can be done through his veins in his case) may point out a root cause and point to treatment options. Furthermore, there is promising experimental therapy for VOD should the Activated Protein C fail - but there are German (and proably US) barriers to getting this substance in the first place and then in a form that he can tolerate (intervenous).
We pray that there is good news regarding some improvement in the VOD - if his liver would begin to function properly, many of the dominos would slow or stop where they are.
His enemy continues to be time.
Thank you for your continued fervent prayer on his behalf.